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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK4
All Species:
42.73
Human Site:
Y270
Identified Species:
72.31
UniProt:
Q9NR20
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR20
NP_003836.1
520
59608
Y270
T
Y
I
Q
S
R
F
Y
R
S
P
E
V
I
L
Chimpanzee
Pan troglodytes
XP_001158495
520
59654
Y270
T
Y
I
Q
S
R
F
Y
R
S
P
E
V
I
L
Rhesus Macaque
Macaca mulatta
XP_001101112
520
59434
Y270
T
Y
I
Q
S
R
F
Y
R
S
P
E
V
I
L
Dog
Lupus familis
XP_534917
565
65190
Y318
T
Y
I
Q
S
R
F
Y
R
S
P
E
V
I
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8BI55
632
72542
Y385
T
Y
I
Q
S
R
F
Y
R
S
P
E
V
I
L
Rat
Rattus norvegicus
Q4V8A3
586
65492
I340
C
D
L
K
P
E
N
I
L
L
K
H
H
G
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509988
466
52101
R231
G
L
S
L
A
V
I
R
R
F
T
Y
S
V
L
Chicken
Gallus gallus
Q5ZIU3
526
59419
I279
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
Frog
Xenopus laevis
Q2TAE3
750
84138
Y319
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
Zebra Danio
Brachydanio rerio
XP_693389
634
72240
Y378
T
Y
I
Q
S
R
F
Y
R
S
P
E
V
I
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3D5
722
79590
Y364
T
Y
I
Q
S
R
F
Y
R
S
P
E
V
I
L
Honey Bee
Apis mellifera
XP_396369
614
68978
Y349
T
Y
L
Q
S
R
F
Y
R
S
P
E
V
I
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51568
400
46206
Y165
D
F
L
K
R
N
K
Y
S
A
F
P
L
A
L
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
Y536
T
Y
I
Q
S
R
F
Y
R
A
P
E
I
I
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.8
89.2
76.9
N.A.
65.3
38.7
N.A.
54.2
43.1
28
48.9
N.A.
37.5
42.3
N.A.
N.A.
Protein Similarity:
100
99
91.5
81.2
N.A.
71.5
53.9
N.A.
66.1
59.7
43.3
61.8
N.A.
50.1
59.1
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
0
N.A.
13.3
0
86.6
100
N.A.
100
93.3
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
13.3
N.A.
26.6
20
93.3
100
N.A.
100
100
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.8
22.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
42.5
36.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
86.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
100
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
0
0
0
15
0
0
0
8
0
% A
% Cys:
15
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
15
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
15
0
0
0
0
0
72
0
0
0
% E
% Phe:
0
8
0
0
0
0
72
0
0
8
8
0
0
0
0
% F
% Gly:
8
0
0
0
0
0
0
0
0
0
0
0
0
15
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
8
0
0
% H
% Ile:
0
0
65
0
0
0
8
15
0
0
0
0
8
65
0
% I
% Lys:
0
0
0
22
0
0
8
0
0
0
15
0
0
0
0
% K
% Leu:
0
8
29
8
0
0
0
0
15
15
0
0
8
8
86
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
8
15
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
15
0
0
0
0
0
72
8
0
0
0
% P
% Gln:
8
0
0
72
0
0
0
0
0
0
0
8
8
0
0
% Q
% Arg:
0
0
0
0
8
72
0
8
79
0
0
0
0
0
15
% R
% Ser:
0
0
8
0
72
0
0
0
8
65
0
0
8
0
0
% S
% Thr:
65
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% T
% Val:
0
0
0
0
0
8
0
0
0
0
0
0
65
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
72
0
0
0
0
0
79
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _